This item is under embargo and not available online per the author's request. For access information, please visit http://libanswers.wustl.edu/faq/5640.

ORCID

http://orcid.org/0000-0003-3029-1040

Date of Award

Winter 1-15-2021

Author's School

Graduate School of Arts and Sciences

Author's Department

Chemistry

Degree Name

Doctor of Philosophy (PhD)

Degree Type

Dissertation

Abstract

Microelectrode arrays contain collections of spatially isolated electrodes that can be individually addressed. Thus, the arrays have the potential to support synthesis of molecular libraries if unique members of the library can be located next to unique electrodes in the array. The result would be an intriguing platform for screening the molecules in the library against biological receptors in order to identify high-affinity ligands for those targets, especially since the arrays themselves can be directly used in the signaling studies. To expand the capabilities of the arrays, the goal of this thesis is to develop the new array chemistry needed to build a larger library. Our efforts in this area started with improving the surface coating on the array that supports every synthetic and analytic experiment conducted on the arrays. Once we had an optimized surface for performing chemistry on the arrays, I investigated protecting group strategies for parallel synthesis on the arrays. This eventually led me to develop new chemistry for diversifying molecules on the array that also facilitates characterization of the array-bound substrates. This new chemistry will help us to more fully utilize the bioanalytical potential of the arrays.

Language

English (en)

Chair and Committee

Kevin Moeller

Committee Members

Jonathan Barnes, John-Stephen Taylor, Timothy Wencewicz, Zhen He,

Available for download on Thursday, December 02, 2021

Included in

Chemistry Commons

Share

COinS