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Date of Award
Doctor of Philosophy (PhD)
Proteomic analyses of multispecies systems provide detailed portraits of molecular processes that can expand our understanding of the basic principles of biology and human health. Understanding these systems requires analytical, computational, and statistical methods that are capable of yielding taxon-specific data in samples containing inseparable mixtures of comingled species. In this dissertation, new methods and computational resources are presented to facilitate the analysis of multispecies proteomics. These methods and tools are then applied to patient-derived xenografts to reveal the molecular education of stromal tissue by tumors using species-specific proteomics, and to the human oral microbiome to estimate its composition and simultaneously identify human and microbial proteins using a de novo approach.
Chair and Committee
Jason Held, Ron Bose, Kian-Huat Lim, Kristen Naegle,
Mooradian, Arshag, "Computational Approaches for Multispecies and Metaproteomic Analyses" (2019). Arts & Sciences Electronic Theses and Dissertations. 1932.
Available for download on Tuesday, August 15, 2119