Date of Award
Master of Arts (AM/MA)
Spatial navigation deficits are observed in Alzheimer disease (AD) cross-sectionally, but prediction of longitudinal clinical decline has been less examined. Cognitive mapping (CM) was assessed in 95 participants and route Learning (RL) was assessed in 65 participants at baseline. Clinical progression over an average of 4.16 years was assessed using the Clinical Dementia Rating scale. Relative predictive ability of these tasks was compared to episodic memory, hippocampal volume and cerebrospinal fluid (CSF) biomarkers (ptau181/Aβ42 ratio). CM and RL were significant predictors of clinical progression (ps181/Aβ42 in prediction (psTaken together the results suggest that baseline spatial navigation performance may be appropriate for assessing risk of clinical progression.
Chair and Committee
Jeffrey Zacks, Brian Carpenter
Hendershott, Taylor, "Spatial Navigation Ability as a Predictor of Increased Clinical Impairment" (2019). Arts & Sciences Electronic Theses and Dissertations. 1878.