This item is under embargo and not available online per the author's request. For access information, please visit http://libanswers.wustl.edu/faq/5640.

Title

Dynamic Aggregation and Amphiphilic Behavior of Synthetic Anion Transpofers

Date of Award

Summer 8-15-2010

Author's School

Graduate School of Arts and Sciences

Author's Department

Chemistry

Degree Name

Doctor of Philosophy (PhD)

Degree Type

Dissertation

Abstract

The work reported in this thesis is focused on various synthetic ion channels. A broad range of successful approaches has been realized in the design and characterization of synthetic ionophores. Studies in this area promise a better understanding of supramolecular interactions, membrane interactions, and ultimately the development of novel pharmaceuticals for diseases and ailments involving impaired channel function. As new structures are designed and reported, it is important not only to demonstrate function, but also to correlate function to dynamics, self-assembly, and supramolecular membrane interactions.

In this thesis, two distinct groups of amphiphilic synthetic anion transporters (SATs) are presented. Their transport abilities were assessed with vesicle release experiments and planar bilayer conduction experiments. Characterization of supramolecular interactions involved in aggregation, membrane insertion, and interfacial monolayer stability employed an array of analytical techniques including dynamic light scattering, transmission electron microscopy, Langmuir trough experiments, and Brewster angle microscopy.

Language

English (en)

Chair and Committee

George W. Gokel

Committee Members

Kevin Moeller, John-Stephen A. Taylor, Vladimir Birman, Peter Gaspar, Jim Janetka, Keith Stine

Comments

Permanent URL: https://doi.org/10.7936/K7028PF2

This document is currently not available here.

Share

COinS