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Date of Award

Spring 5-15-2018

Author's School

Graduate School of Arts and Sciences

Author's Department

Biology & Biomedical Sciences (Immunology)

Degree Name

Doctor of Philosophy (PhD)

Degree Type

Dissertation

Abstract

Germline-encoded receptors recognizing common pathogen-associated molecular patterns are a central element of the innate immune system and play an important role in shaping the host response to infection. Many of the innate immune molecules central to these signaling pathways are evolutionarily conserved, from flies to mice and humans. LysMD3 is a novel molecule containing a putative peptidoglycan-binding domain that has orthologs in humans, mice, zebrafish, worms, and flies. In this dissertation we investigated the role of LysMD3 in the immune response to infection and its role in regulating the host response to the commensal microbiota in two model organisms. We found that mouse LysMD3 is a type II integral membrane protein that co-localizes with GM130+ structures, consistent with localization to the cis-Golgi. Unfortunately, we could not define a role for LysMD3 in the mammalian response to infection. Additional studies will be required to further evaluate the importance of this evolutionarily conserved molecule.

Language

English (en)

Chair and Committee

Herbert W. Virgin

Committee Members

Paul M. Allen, Marco Colonna, Mary C. Dinauer, Shabaana A. Khader,

Comments

Permanent URL: https://doi.org/10.7936/K72V2FK7

Available for download on Sunday, May 15, 2118

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