Date of Award
Spring 5-15-2018
Degree Name
Doctor of Philosophy (PhD)
Degree Type
Dissertation
Abstract
Germline-encoded receptors recognizing common pathogen-associated molecular patterns are a central element of the innate immune system and play an important role in shaping the host response to infection. Many of the innate immune molecules central to these signaling pathways are evolutionarily conserved, from flies to mice and humans. LysMD3 is a novel molecule containing a putative peptidoglycan-binding domain that has orthologs in humans, mice, zebrafish, worms, and flies. In this dissertation we investigated the role of LysMD3 in the immune response to infection and its role in regulating the host response to the commensal microbiota in two model organisms. We found that mouse LysMD3 is a type II integral membrane protein that co-localizes with GM130+ structures, consistent with localization to the cis-Golgi. Unfortunately, we could not define a role for LysMD3 in the mammalian response to infection. Additional studies will be required to further evaluate the importance of this evolutionarily conserved molecule.
Language
English (en)
Chair and Committee
Herbert W. Virgin
Committee Members
Paul M. Allen, Marco Colonna, Mary C. Dinauer, Shabaana A. Khader,
Recommended Citation
Yokoyama, Christine Chieko, "Functions of the Novel Molecule LysMD3 in Mice and Flies" (2018). Arts & Sciences Electronic Theses and Dissertations. 1602.
https://openscholarship.wustl.edu/art_sci_etds/1602
Included in
Allergy and Immunology Commons, Cell Biology Commons, Immunology and Infectious Disease Commons, Medical Immunology Commons, Microbiology Commons
Comments
Permanent URL: https://doi.org/10.7936/K72V2FK7