Date of Award

Spring 5-2017

Author's School

Graduate School of Arts and Sciences

Author's Department


Degree Name

Master of Arts (AM/MA)

Degree Type



Another interesting feature of this OMS circuit is the strong surround suppression occurring in the inner retina, which enables both VG3-ACs and W3-RGCs to remain silent to the global image motion. Pharmacological evidence suggested wide-field and/or spiking ACs are the source of the inhibition. The specific AC types, however, have not been identified. To address this question, in chapter 3, I explored candidate cell types using transgenic mouse lines expressing Cre recombinase, mainly tyrosine hydroxylase (TH)-Cre transgenic mice. In 2-photon guided patch clamp recordings, response patterns of TH2-ACs to object motion visual stimuli corresponded to inhibitory inputs of both VG3-ACs and W3-RGCs. Through optogenetics, functional connectivity of TH2-ACs to VG3-ACs and W3-RGCs is tested. Then, in order to understand how TH2-ACs contribute to the OMS circuit, I generated conditional knockouts of the vesicular inhibitory amino acid transporter (VIAAT) and evaluate responses of VG3-ACs and W3-RGCs to motion visual stimuli.


English (en)

Chair and Committee

Ian G. Dobbins

Committee Members

David A. Balota, Julie Bugg


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