Date of Award
Spring 5-2017
Degree Name
Bachelor of Arts (A.B.)
Restricted/Unrestricted
Unrestricted
Abstract
Over the past two and a half years, I have studied fundamental aspects of astrocyte biology by investigating the existence and mechanism of astrocyte local translation peripherally around tripartite synapses consisting of pre- and post-synaptic neuron terminals and an associated astrocyte. Astrocytes are critical components of central nervous system synapses (which are predominately tripartite in nature); thus, it is important to consider how astrocyte dysregulation and dysfunction could contribute to the pathogenesis of diseases of synaptic connectivity such as autism spectrum disorders, Alzheimer’s disease, seizure disorders, and more. Overall, my projects involved the development of novel methods to identify astrocyte-specific mRNA targets and to visualize and measure local translation.
Mentor
Joseph Dougherty, Ph.D., & Kristina Sakers
Recommended Citation
Khazanchi, Rohan, "Investigating Localization and Activity-Dependent Translation of Astrocyte mRNA" (2017). Senior Honors Papers / Undergraduate Theses. 8.
https://openscholarship.wustl.edu/undergrad_etd/8
Included in
Cell Biology Commons, Molecular and Cellular Neuroscience Commons, Neurosciences Commons