Author's School

Graduate School of Arts & Sciences

Author's Department/Program

Chemistry

Language

English (en)

Date of Award

January 2010

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Chair and Committee

George Gokel

Abstract

Synthetic ion transporters: new analytical approaches for the investigation of ion binding and transport by Ionut Alexandru Carasel Doctor of Philosophy in Chemistry Washington University in St. Louis, 2010 Dr. George W. Gokel, co-Chair Dr. Kevin Moeller, co-Chair The work reported in this dissertation focuses on synthetic ion transporters: SATs). SATs have a relatively simple chemical structure but they aggregate, self-assemble and insert in biological membranes much in the same way as their much more complex naturally occurring analogs. This makes SATs valuable tools for the investigation of these supramolecular and membrane related processes with the final goal of developing new therapeutical agents useful in the treatment of conditions stemming from ionic imbalances. Two families of synthetic anion transporters are studied in this dissertation: pyrogallol[4]arene derivatives and dianilides of isophthalic and dipicolininc acids. Experiments aimed at investigating their solution behavior, anion binding properties and the strength of the interactions present in the host*anion adducts employed analytical techniques such as high performance liquid chromatography, electrospray mass spectrometry, UV-vis and NMR spectroscopy. Insights derived from these experiments were instrumental to our understanding of the stability and transport mechanisms pertaining to these two families of compounds.

DOI

https://doi.org/10.7936/K7KP8064

Comments

Permanent URL: http://dx.doi.org/10.7936/K7KP8064

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