Author's School

Graduate School of Arts & Sciences

Author's Department/Program

Physics

Language

English (en)

Date of Award

January 2011

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Chair and Committee

Jeffrey Neil

Abstract

Preterm infants are particularly susceptible to cerebral injury, and electroencephalographic: EEG) recordings provide an important diagnostic tool for determining cerebral health. However, interpreting these EEG recordings is challenging and requires the skills of a trained electroencephalographer. Because these EEG specialists are rare, an automated interpretation of newborn EEG recordings would increase access to an important diagnostic tool for physicians. To automate this procedure, we employ a novel Bayesian approach to compute the probability of EEG features: waveforms) including suppression, delta brushes, and delta waves. The power of this approach lies not only in its ability to closely mimic the techniques used by EEG specialists, but also its ability to be generalized to identify other waveforms that may be of interest for future work. The results of these calculations are used in a program designed to output simple statistics related to the presence or absence of such features. Direct comparison of the software with expert human readers has indicated satisfactory performance, and the algorithm has shown promise in its ability to distinguish between infants with normal neurodevelopmental outcome and those with poor neurodevelopmental outcome.

Comments

Permanent URL: http://dx.doi.org/10.7936/K7ZW1J1B

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