This item is under embargo and not available online per the author's request. For access information, please visit http://libanswers.wustl.edu/faq/5640.

Date of Award

Spring 5-15-2017

Author's School

School of Engineering & Applied Science

Author's Department

Biomedical Engineering

Degree Name

Doctor of Philosophy (PhD)

Degree Type

Dissertation

Abstract

Radioembolization of yttrium-90 (Y-90) microspheres is used to treat primary and secondary cancers in the liver. Though this therapy has existed for decades, the treatment is not well optimized from treatment planning to post-procedural assessment. Recently, there has been a surge to utilize the small positron yield from the radioactive decay of Y-90 for post-radioembolization positron emission tomography (PET) imaging of the microsphere activity distribution. These images provide promise for dosimetry assessment, identifying extrahepatic uptake and possible under-dosed lesions that may benefit from subsequent therapy. However, due to the low positron statistics and high flux of Bremsstrahlung radiation, PET imaging of Y-90 presents with its own unique set of challenges. In this work, we optimized the PET imaging acquisition and reconstruction parameters when imaging with a hybrid PET/MRI scanner to offer the most accurate images for quantitative dosimetric applications. We then tested the variability of imaging Y-90 with PET across multiple institutions in a world-wide phantom study in preparation for a multi-institutional phase I/II clinical trial. Lastly, we determined the clinical utility of using Y-90 PET-based dosimetry to predict clinical outcomes and assess how well it correlates with pre-treatment imaging.

Language

English (en)

Chair

Parag J. Parikh

Committee Members

Mark A. Anastasio, Hong Chen, Harold H. Li, Richard L. Wahl,

Comments

Permanent URL: https://doi.org/10.7936/K7R20ZSN

Available for download on Wednesday, April 18, 2018

Included in

Biomedical Commons

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