CBAC Seminar Series Videos
 
Massively-Parallel All-Optical Cardiac Electrophysiology

Title

Massively-Parallel All-Optical Cardiac Electrophysiology

Files

Date

Spring 4-17-2017

Document Type

Seminar Series

Abstract

Optical targeting (stimulation or recording) allows distributed parallel access to thousands and even millions of cells and locations at the same time, and within the tissue setting; optical targeting is high-throughput by nature. In this talk, I will discuss and demonstrate the combination of optogenetic stimulation with optical imaging of electrical activity in cardiomyocytes, i.e. the realization of “all-optical electrophysiology” in a high-throughput manner (HTS). Examples will include demonstration of cardiac “wave steering” by light and the use of a new fully-automated all-optical HTS platform (OptoDyCE) for drug screening using patient-derived cardiomyocytes (iPS-CMs).

Biography

Professor of Biomedical Engineering; Director, Cardiac Optogenetics and Optical Imaging Laboratory The George Washington University

Research/Clinical Interests

http://bme.sunysb.edu/labs/eentcheva/

Massively-Parallel All-Optical Cardiac Electrophysiology

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