Author's Department

Biology

Document Type

Article

Publication Date

5-2013

Abstract

The bacterial mechanosensitive channel MscS provides an excellent model system for the study of mechanosensitivity and for investigations into the cellular response to hypoosmotic shock. Numerous studies have elucidated the structure, function and gating mechanism of Escherichia coli MscS, providing a wealth of information for the comparative analysis of MscS family members in bacteria, archaea, fungi and plants. We recently reported the electrophysiological characterization of MscS-Like (MSL)10, a MscS homolog from the model flowering plant Arabidopsis thaliana. Here we summarize our results and briefly compare MSL10 to previously described members of the MscS family. Finally, we comment on how this and other recently published studies illuminate the possible mechanisms by which ion selectivity is accomplished in this fascinating family of channels.

Comments

Final author version of article published in Channels (Austin) 2013 Apr 16;7(3): 215-220. http://dx.doi.org/10.4161/chan.24505

DOI

10.4161/chan.24505

Embargo Period

6-10-2013

Included in

Biology Commons

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